Are you passionate about in vivo obesity research and have extensive knowledge of metabolism and drug discovery? Then please read further! We are seeking a talented Principal Scientist to be part of Novo Nordisk and participate in changing the quality of life for millions of people with cardiometabolic diseases. The positionYou will be a disease expert within obesity with a strong background in metabolism and drug discovery. The role will require leadership of – and participation in – drug discovery project teams, cross-functional planning of complex pharmacology studies and other project team activities related to new targets and obesity in general. Mentoring and supervision of technical/junior staff is an integral part of the job. You will join a global team of highly skilled professionals and you will work with CROs and academic collaborators in order to provide project teams with critical data and support. Responsibilities include: Spearheading scientific excellence in obesity biology to actively engage in target discovery, innovation, and project progression. Design and conduct key experiments to validate human relevance and explore pharmacokinetics, pharmacodynamics, and mode of action, both internally and externally always applying the highest scientific standards and assessing available translational tools. Development and implementation of new models, methods, and technologies for in vivo/ex vivo testing of biological activity of new anti-obesity targets. Responsible for writing protocols, data analysis, interpretation, record keeping, reporting, and communication of results.Communicate complex multidisciplinary topics to Obesity Biology (in vitro), Translational Medicine, Bioinformatics, Global Drug Discovery Leadership and project teams as well as relevant governance bodies. Collaborate with internal stakeholders within a matrix environment as well as external scientific advisors and academic centres of expertise. QualificationsYou hold a Ph.D. within the cardiometabolic field and have significant post-graduate experience. Preferably at least 5 years of experience in pharma R&D. Experience with other cardiometabolic diseases, incl. diabetes, NASH, cardiovascular disease, and renal disease is an advantage. Strong scientific knowledge is a must and a proven scientific track-record of contributing to the delivery of high-quality drug discovery candidates into clinical development is a huge advantage. The ideal candidate is highly skilled in establishing, optimizing, validating, and running obesity studies in rodents and/or large animals. Experience with translational aspects of the model(s) applied and a solid scientific network as well as international experience will be highly valued. In addition to your scientific profile, you are a dedicated, open-minded, and innovative team player with good collaboration and problem-solving skills, highly proficient in spoken and written English. About the departmentIntegrated Physiology Research is a VP area encompassing all in vivo pharmacology departments in the cardiometabolic space in the research part of Novo Nordisk. As part of Novo Nordisk’s strategy within cardiometabolic diseases, this VP area is focused on target identification, validation, and deep pre-clinical characterisation of novel treatment options for obesity, diabetes, liver disease, cardiovascular disease, and renal disease. In close collaboration with our in vitro colleagues, we strive to identify and mature pharmaceutical approaches that will benefit patients living with obesity or other serious chronic disease. We establish, validate, and use in vivo models in rodents (mice and rats) and large animals (e.g. pigs, dogs, and non-human primates) and perform pharmacokinetic, pharmacodynamic, and mode-of-action studies to characterize potential new drug candidates. Experimental work is carried out by technical staff and scientists as well as outsourced as contract research. Working at Novo NordiskThe department is part of Global Drug Discovery, which specialises in the discovery of biological medicines for the treatment of diabetes, obesity, haemophilia, chronic liver disease, chronic kidney disease, and cardiovascular diseases. We always strive for excellence and continuously develop our expertise to stay ahead – both as a company and as individuals. We believe that innovation and creativity thrive in a healthy and engaging working environment. Therefore, we give you the opportunity to bring your personal ambition and passion to work to improve the quality of life of the patients. ContactFor further information, please contact Tanja Xenia Pedersen (large animals, phone +45 3077 5884, email@example.com) or Sara Toftegaard Hjuler (rodents, phone +45 3079 2928, firstname.lastname@example.org). Deadline30 June 2022 Please note that applications will be reviewed continuously, thus the advert may close prior to the indicated deadline. You do not need to attach a cover letter to your application, but please include a few sentences about why you are applying in your resume or CV. To ensure an efficient and fair recruitment process, please refrain from adding a photo in your CV. We commit to an inclusive recruitment process and equality of opportunity for all our job applicants. At Novo Nordisk we recognize that it is no longer good enough to aspire to be the best company in the world. We need to aspire to be the best company for the world and we know that this is only possible with talented employees with diverse perspectives, backgrounds and cultures. We are therefore committed to creating an inclusive culture that celebrates the diversity of our employees, the patients we serve and communities we operate in. Together, we’re life changing.